Skip to main content
. 2015 Mar 24;3:e856. doi: 10.7717/peerj.856

Table 2. List of genes and SNPs associated with body mass index (BMI) or binary obesity from genome-wide association studies (GWAS).

Gene SNPs Chrom. Phenotype Reference
ADCY9 rs2531995 16 Obesity Berndt, SI. 2013. Nat Genet
AGBL4 rs657452 1 BMI Locke, AE. 2015. Nature
ASB4 rs6465468 7 BMI Locke, AE. 2015. Nature
BDNF rs6265, rs4923461,rs10767664, rs2030323, rs988712 11 BMI, Obesity, Overweight Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Jiao, H. 2011. BMC Med Genomics, Okada, Y. 2012. Nat Genet, Wen, W. 2012. Nat Genet 2012
BRE rs116612809 2 BMI Gong, J. 2013. Am J Hum Genet
C9orf93 rs4740619 9 BMI Locke, AE. 2015. Nature
CADM1 rs12286929 11 BMI Locke, AE. 2015. Nature
CADM2 rs13078807 3 BMI, Overweight Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
CALCR rs9641123 7 BMI Locke, AE. 2015. Nature
CBLN1 rs2080454 16 BMI Locke, AE. 2015. Nature
CDKAL1 rs2206734, rs9356744 6 BMI Okada, Y. 2012. Nat Genet, Wen, W. 2012. Nat Genet 2012
CLIP1 rs11057405 12 BMI Locke, AE. 2015. Nature
CREB1, KLF7 rs17203016 2 BMI Locke, AE. 2015. Nature
EHBP1 rs11688816 2 BMI Locke, AE. 2015. Nature
ELAVL4 rs11583200 1 BMI Locke, AE. 2015. Nature
EPB41L4B, C9orf4 rs6477694 9 BMI Locke, AE. 2015. Nature
ERBB4 rs7599312 2 BMI Locke, AE. 2015. Nature
ETS2 rs2836754 21 BMI Locke, AE. 2015. Nature
ETV5 rs7647305, rs9816226 3 BMI, Obesity, Overweight Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
FAIM2 rs7138803, rs7132908 12 BMI, Obesity, Overweight Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Paternoster, L. 2011. PLoS One, Bradfield, JP. 2012. Nat Genet, Berndt, SI. 2013. Nat Genet
FANCL rs887912 2 BMI, Obesity, Overweight Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
FANCL, FLJ30838 rs12617233 2 BMI Guo, Y. 2012. Hum Mol Genet
FHIT rs2365389 3 BMI Locke, AE. 2015. Nature
FIGN rs1460676 2 BMI Locke, AE. 2015. Nature
FLJ35779 rs2112347 5 BMI, Obesity, Overweight Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
FOXO3, HSS00296402 rs9400239 6 BMI Locke, AE. 2015. Nature
FTO rs9939609, rs9930506, rs1121980, rs1421085, rs8050136, rs1558902, rs17817449, rs12149832, rs9940128, rs62033400, rs1421085, rs1121980, rs9936385, rs9941349, rs3751812, rs1558902, rs17817449 16 BMI, Obesity, Childhood Obesity Dina, C. 2007. Nat Genet, Hinney, A. PLoS One. 2007, Frayling, TM. 2007. Science, Scuteri, A. 2007. PLoS Genet, Loos, RJ. 2008. Nat Genet, Meyre, D. 2009. Nat Genet, Thorleifsson, G. 2009. Nat Genet, Willer, CJ. 2009. Nat Genet, Cho, YS. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Scherag, A. 2010. PLoS Genet, Paternoster, L. 2011. PLoS One, Wang, K. 2011. PLoS One, Bradfield, JP. 2012. Nat Genet, Wen, W. 2012. Nat Genet, Okada, Y. 2012. Nat Genet, Guo, Y. 2012. Hum Mol Genet, Graff, M. 2013. Hum Mol Genet, Pei, YF. 2013. Hum Mol Genet, Berndt, SI. 2013. Nat Genet, Wheeler, E. 2013. Nat Genet
GBE1 rs3849570 3 BMI Locke, AE. 2015. Nature
GDF15, PGPEP1 rs17724992 19 BMI Locke, AE. 2015. Nature
GIPR rs2287019, rs11671664 19 BMI Speliotes, EK. 2010. Nat Genet, Wen, W. 2012. Nat Genet, Okada, Y. 2012. Nat Genet
GNAT2 rs17024258 1 Obesity Berndt, SI. 2013. Nat Genet
GNPDA2 rs10938397, rs13130484, rs348495 4 BMI, Obesity, Overweight Willer, CJ. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Graff, M. 2013. Hum Mol Genet, Berndt, SI. 2013. Nat Genet
GP2 rs12597579 16 BMI Wen, W. 2012. Nat Genet 2012
GPRC5BB rs12444979 16 BMI, Obesity, Overweight Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
GRID1 rs7899106 10 BMI Locke, AE. 2015. Nature
GRP rs7243357 18 BMI Locke, AE. 2015. Nature
GRP120 rs116454156 10 Obesity Ichimura, A. 2012. Nature
HHIP rs11727676 4 BMI Locke, AE. 2015. Nature
HIF1AN rs17094222 10 BMI Locke, AE. 2015. Nature
HIP1, PMS2L3, PMS2P5, WBSCR16 rs1167827 7 BMI Locke, AE. 2015. Nature
HMGA1 rs206936 6 BMI Speliotes, EK. 2010. Nat Genet
HNF4G rs4735692 8 Obesity Berndt, SI. 2013. Nat Genet
HOXB5 rs9299 17 Childhood Obesity Bradfield, JP. 2012. Nat Genet
HS6ST3 rs7989336 13 Obesity Berndt, SI. 2013. Nat Genet
HSD17B12 rs2176598 11 BMI Locke, AE. 2015. Nature
IFNGR1, OLIG3 rs13201877 6 BMI Locke, AE. 2015. Nature
KAT8, ZNF646, VKORC1, ZNF668, STX1B, FBXL19 rs9925964 16 BMI Locke, AE. 2015. Nature
KCNK3 rs11126666 2 BMI Locke, AE. 2015. Nature
KCNMA1 rs2116830 101 Obesity Jiao, H. 2011. BMC Med Genomics
KCTD15 rs11084753, rs29941 19 BMI Willer, CJ. 2009. Nat Genet, Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet
KLF9 rs11142387 9 BMI Okada, Y. 2012. Nat Genet
LEPR rs11208659 1 Childhood Obesity Wheeler, E. 2013. Nat Genet
LMX1B rs10733682 9 BMI Locke, AE. 2015. Nature
LOC100287559, BBS4 rs7164727 15 BMI Locke, AE. 2015. Nature
LOC284260, RIT2 rs7239883 18 BMI Locke, AE. 2015. Nature
LOC285762 rs9374842 6 BMI Locke, AE. 2015. Nature
LPIN2 rs643507 18 Obesity (Asthmatic patients) Melen, E. 2013. Clin Exp Allergy
LRP1B rs2890652 2 BMI Speliotes, EK. 2010. Nat Genet
LRRN6C rs10968576 9 BMI, Obesity Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
MAF rs1424233 16 Obesity Meyre, D. 2009. Nat Genet
MAP2K5 rs2241423, rs4776970, rs997295 15 BMI, Obesity, Overweight Speliotes, EK. 2010. Nat Genet, Wen, W. 2012. Nat Genet 2012, Guo, Y. 2012. Hum Mol Genet, Berndt, SI. 2013. Nat Genet
MAPK3, KCTD13, INO80E, TAOK2, YPEL3, DOC2A, FAM57B rs4787491 16 BMI Locke, AE. 2015. Nature
MC4R rs17782313, rs571312, rs12970134, rs2331841, rs6567160, rs8089364, rs7234864, rs723486, rs7227255, rs2229616, rs17782313, rs17700144,rs663129, rs571312, rs476828 18 BMI, Obesity, Overweight Loos, RJ. 2008. Nat Genet, Thorleifsson, G. 2009. Nat Genet, Meyre, D. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Scherag, A. 2010. PLoS Gene, Paternoster, L. 2011. PLoS One, Guo, Y. 2012. Hum Mol Genet, Okada, Y. 2012. Nat Genet, Wen, W. 2012. Nat Genet, Bradfield, JP. 2012. Nat Genet, Berndt, SI. 2013. Nat Genet, Wheeler, E. 2013. Nat Genet, Graff, M. Hum Mol Genet. 2013, Pei, YF. Hum Mol Genet. 2013
MIR548A2 rs1441264 13 BMI Locke, AE. 2015. Nature
MIR548X2, PCDH9 rs9540493 13 BMI Locke, AE. 2015. Nature
MRPS33P4 rs13041126 20 Obesity Berndt, SI. 2013. Nat Genet
MTCH2 rs10838738, rs3817334 11 BMI, Obesity, Overweight Willer, CJ. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
MTIF3 rs4771122 13 Speliotes, EK. 2010. Nat Genet
NAV1 rs2820292 1 BMI Locke, AE. 2015. Nature
NEGR1 rs2815752, rs2568958, rs1993709 1 BMI, Obesity, Overweight Willer, CJ. 2009. Nat Genet, Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet, Wheeler, E. 2013. Nat Genet
NLRC3 rs758747 16 BMI Locke, AE. 2015. Nature
NPC1 rs1805081 18 Obesity Meyre, D. 2009. Nat Genet
NRXN3 rs10150332 14 BMI, Obesity Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
NT5C2, CYP17A1, SFXN2 rs11191560 10 BMI Locke, AE. 2015. Nature
NTRK2 rs1211166 9 BMI Guo, Y. 2012. Hum Mol Genet
NUP54, SCARB2 rs17001654 4 BMI Locke, AE. 2015. Nature
OLFM4 rs9568856, rs9568867 13 Obesity Bradfield, JP. 2012. Nat Genet, Berndt, SI. 2013. Nat Genet
PACS1 rs564343 11 Childhood Obesity Wheeler, E. 2013. Nat Genet
PARK2 rs13191362 6 BMI Locke, AE. 2015. Nature
PCSK1 rs261967, rs6232, rs6234, rs6235 5 BMI, Obesity Benzinou, M. 2008. Nat Genet, Wen, W. 2012. Nat Genet
PLCD4, CYP27A1, USP37, TTLL4, STK36, ZNF142,RQCD1 rs492400 2 BMI Locke, AE. 2015. Nature
PMS2L11 rs2245368 7 BMI Locke, AE. 2015. Nature
POMC rs713586, rs6545814, rs1561288, rs6752378, rs10182181 2 BMI, Obesity, Overweight Speliotes, EK. 2010. Nat Genet, Wen, W. 2012. Nat Genet 2012, Bradfield, JP. 2012. Nat Genet, Berndt, SI. 2013. Nat Genet, Graff, M. 2013. Hum Mol Genet
PRKCH rs1957894 14 Childhood Obesity Wheeler, E. 2013. Nat Genet
PRKD1 rs11847697, rs12885454 14 BMI Speliotes, EK. 2010. Nat Genet, Locke, AE. 2015. Nature
PTBP2 rs1555543 1 BMI Speliotes, EK. 2010. Nat Genet
QPCTL rs2287019 19 Obesity, Overweight Berndt, SI. 2013. Nat Genet
RABEP1 rs1000940 17 BMI Locke, AE. 2015. Nature
RALYL rs2033732 8 BMI Locke, AE. 2015. Nature
RARB rs6804842 3 BMI Locke, AE. 2015. Nature
RASA2 rs16851483 3 BMI Locke, AE. 2015. Nature
RMST rs11109072 12 Childhood Obesity Wheeler, E. 2013. Nat Genet
RPL27A rs11042023 11 Obesity Berndt, SI. 2013. Nat Genet
RPTOR rs7503807 17 Overweight Berndt, SI. 2013. Nat Genet
SBK1, APOBR rs2650492 16 BMI Locke, AE. 2015. Nature
SCG3, DMXL2 rs3736485 15 BMI Locke, AE. 2015. Nature
SDCCAG8 rs12145833 1 Childhood Obesity Scherag, A. 2010. PLoS Gene
SEC16B rs10913469, rs543874, rs574367, rs516636, rs591120 1 BMI, Obesity, Overweight Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Bradfield, JP. 2012. Nat Genet, Berndt, SI. 2013. Nat Genet, Graff, M. 2013. Hum Mol Genet, Wen, W. 2012. Nat Genet, Okada,Y. 2012. Nat Genet
SH2B1 rs7498665, rs4788102, rs7359397, rs4788099 16 BMI, Obesity, Overweight Willer, CJ. 2009. Nat Genet, Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Guo, Y. 2012. Hum Mol Genet, Berndt, SI. 2013. Nat Genet
SLC39A8 rs13107325 4 BMI Speliotes, EK. 2010. Nat Genet
SMG6, N29617 rs9914578 17 BMI Locke, AE. 2015. Nature
STXBP6 rs10132280 14 BMI Locke, AE. 2015. Nature
TAL1 rs977747 1 BMI Locke, AE. 2015. Nature
TCF7L2 rs7903146 10 BMI Locke, AE. 2015. Nature
TDRG1, LRFN2 rs2033529 6 BMI Locke, AE. 2015. Nature
TFAP2B rs987237, rs734597, rs2272903 6 BMI, Obesity, Overweight Speliotes, EK. 2010. Nat Genet, Paternoster, L. 2011. PLoS One, Guo, Y. 2012. Hum Mol Genet, Berndt, SI. 2013. Nat Genet
TLR4 rs1928295 9 BMI Locke, AE. 2015. Nature
TMEM160 rs3810291, rs3810291 19 BMI, Obesity Speliotes, EK. 2010. Nat Genet, Berndt, SI. 2013. Nat Genet
TMEM18 rs6548238, rs7561317, rs2867125, rs12463617, rs4854344 2 BMI, Obesity, Overweight Willer, CJ. 2009. Nat Genet, Thorleifsson, G. 2009. Nat Genet, Speliotes, EK. 2010. Nat Genet, Guo, Y. 2012. Hum Mol Genet, Bradfield, JP. 2012. Nat Genet, Berndt, SI. 2013. Nat Genet, Wheeler, E. 2013. Nat Genet, Graff, M. 2013. Hum Mol Genet
TNKS rs17150703 8 Childhood Obesity Scherag, A. 2010. PLoS Gene
TNNI3K rs1514175, rs12142020, rs1040070, rs1514174 1 BMI, Obesity Speliotes, EK. 2010. Nat Genet, Bradfield, JP. 2012. Nat Genet, Graff, M. 2013. Hum Mol Genet, Berndt, SI. 2013. Nat Genet
TOMM40, APOE, APOC1 rs2075650 19 BMI Guo, Y. 2012. Hum Mol Genet
TUB rs4929949 11 BMI Speliotes, EK. 2010. Nat Genet
UBE2E3 rs1528435 2 BMI Locke, AE. 2015. Nature
ZBTB10 rs16907751 8 BMI Locke, AE. 2015. Nature
ZNF608 rs48361333 5 BMI Speliotes, EK. 2010. Nat Genet
ZZZ3 rs17381664 1 Obesity Berndt, SI. 2013. Nat Genet