Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 27;9:23. doi: 10.3389/fnint.2015.00023

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Parent, Amarante, Liu, Weikum and Laubach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Optogenetic perturbation of the rostral mPFC prevents persistent licking. (A) Fluorescent GFP expression driven by the non-specific CAG promoter showed evidence for transduction of archaerhodopsin (ArchT) in the rostral mPFC of experimental rats. Control rats either did not show proper alignment of viral field with implanted ferrules or showed no viral expression. (B) Transient perturbation of the rostral mPFC in experimental rats via LED activation consistently decreased licking and bout duration. There was no consistent change in licking by LED in control rats. (C) Transient perturbation of the rostral mPFC in experimental rats via LED activation consistently decreased licking in epochs with LED on relative to epochs with LED off. The optogenetic perturbation of rostral mPFC in experimental rats also reduced the duration of licking bouts. There was no significant change in the number of bouts initiated with the LED activated. (D) The ability to lick within bouts was not affected as there was no significant change in the ILI histogram of licking during epochs between epochs with the LED on and the LED off. *p < 0.05.