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. 2015 Mar 27;3:41. doi: 10.3389/fbioe.2015.00041

Table 1.

PPIase inhibitory activities of novel cycloheximide derivatives and their structures.

Compound Structure IC50 (FKBP12) IC50 (Mip)
MT_30.3 graphic file with name fbioe-03-00041-i001.jpg 2.0 : 0.1 μ M 33.8 ± 8.6 μ M
MT_30.8 graphic file with name fbioe-03-00041-i002.jpg 0.4 ± 0.04 μ M 8.5 ± 2.1 μ M
MT_30.9 graphic file with name fbioe-03-00041-i003.jpg 36.1 ± 4.1 μ M 31.7 ± 7.4 μ M
MT_30.32 graphic file with name fbioe-03-00041-i004.jpg 0.18 ± 0.05 μ M 1.7 ± 0.2 μ M
MT_30.38 graphic file with name fbioe-03-00041-i005.jpg 1.2 ± 0.1 μ M 21.8 ± 3.3 μ M
MT_30.51 graphic file with name fbioe-03-00041-i006.jpg 0.19 ± 0.06 μ M 5.6 ± 1.1 μ M
MT_30.79 graphic file with name fbioe-03-00041-i007.jpg 0.22 ± 0.02 μ M 4.9 ± 0.9 μ M
MT_30.92 graphic file with name fbioe-03-00041-i008.jpg 1.0 ± 0.1 μ M 12.6 ± 1.4 μ M
MT_30.93 graphic file with name fbioe-03-00041-i009.jpg 0.9 ± 0.05 μ M 16.3 ± 2.6 μ M