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. Author manuscript; available in PMC: 2015 Mar 27.
Published in final edited form as: Int J Obes (Lond). 2013 May 21;38(2):183–191. doi: 10.1038/ijo.2013.79

Figure 3. Effect of high-fat diet on plasma and hepatic FGF21.

Figure 3

FGF21 (A) plasma levels and (B) liver mRNA expression in male rhesus monkeys on control diet or a high-fat diet to which they were either resistant or sensitive, n = 3–4/group. Data are means ± SEM; *p < 0.05, **p < 0.01 versus control fed rhesus macaques. Relationship between FGF21 plasma levels and (C) body weight (R2 = 0.9, P < 0.0005, n = 9), and (D) FGF21 liver mRNA (R2 = 0.8, P < 0.002, n = 9) in rhesus monkeys was determined with linear regression analysis. ▲CTR monkeys, □ HFD-resistant monkeys, ● HFD-sensitive monkeys.