Table 2.
Demographics, smoking behavior, and vitals by medication condition.
| Mean, SD or n,% | Guanfacine (n=17) | Placebo (n=16) |
|---|---|---|
|
|
|
|
| Baseline | ||
|
|
|
|
| Age | 35.65, 11.34 | 36.13, 13.12 |
| Gender (male) | 11, 64.7% | 9, 56.3% |
| Race (Caucasian) | 13, 76.5% | 13, 81.3% |
| Education (high school) | 11, 64.7% | 8, 50% |
| Cigarettes per day | 19.84, 7.73 | 16.30, 7.41 |
| Carbon monoxide (ppm) | 30.65, 20.25 | 26.75, 13.20 |
| FTNDa | 6.18, 2.35 | 4.88, 2.13 |
| CESDb | 7.47, 6.88 | 4.56, 4.08 |
| Systolic BP (mmHg) | 119.86, 3.72 | 124.07, 14.39 |
| Diastolic BP (mmHg) | 75.43, 10.01 | 76.83, 9.38 |
| Heart rate (bpm) | 81.58, 12.84 | 80.13, 11.96 |
|
| ||
| Titrationc
| ||
| Cigarettes per day | 18.98, 7.93 | 15.63, 9.34 |
| Systolic BP (mmHg) | 109.07, 13.67 | 119.47, 12.81 |
| Diastolic BP (mmHg) | 64.00, 8.60 | 71.07, 8.06 |
| Heart rate (bpm) | 61.81, 11.18 | 69.97, 10.09 |
All baseline comparisons across medication conditions were not significant (p>.05).
a
Fagerström Test of Nicotine Dependence, FTND (Heatherton et al, 1991), range 1–10 for measure.
b
Center for Epidemiologic Studies Depression Scale, CES-D (Radloff, 1977), range 0–60.
c
Values collected at the end of titration.