Fig. 4.
Relative numbers of DCX cells in controls, cisplatin (Cis), cisplatin with D-methionine (Cis + D-met), and D-methionine (D-met) 7 days after treatment: Numbers were normalized to the control group which was set to 1.0. Rats treated with only cisplatin showed a large and significant reduction in cell density when compared to controls and to animals treated with only D-methionine. D-methionine administered 30 minutes prior to cisplatin kept the number of DCX positive cells comparable to the controls and to animals treated with only D-methionine, while it was significantly larger than in animals treated with cisplatin. There were no significant differences between controls, animals treated with cisplatin plus D-methionine, and animals treated with only D-methionine.