Table 1.
Description of cases screened for BRCA1 and BRCA2 mutations
| Group (Period of ascertainment, years) | Histological subtype 1 | Number of women with ovarian cancer (fallopian tube 2 and primary peritoneal cancers) | Tumour grade | Disease stage 3 | Mean age of diagnosis (range), years | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 | G2 | G3 | Un-classified | I | II | III | IV | ||||
| All (1997–2011) | Serous | 369 (9) | 12 | 62 | 279 | 16 | 25 | 28 | 275 | 40 | 61 (24 – 91) |
| Endometrioid | 30 (0) | 0 | 20 | 9 | 1 | 13 | 2 | 14 | 1 | 58 (41 – 82) | |
| Mixed cell | 32 (0) | 0 | 11 | 21 | 0 | 6 | 2 | 21 | 3 | 57 (36 – 77) | |
| Undifferentiated | 8 (1) | 12 | 0 | 3 | 4 | 2 | 0 | 6 | 0 | 61 (33 – 72) | |
| All types | 439 (10) | 13 | 93 | 312 | 21 | 46 | 32 | 316 | 44 | 61 (24 – 91) | |
| Subgroup (2006–2008) | Serous | 92 (4) | 3 | 11 | 73 | 5 | 7 | 8 | 68 | 9 | 61 (38 – 82) |
| Endometrioid | 9 (0) | 0 | 7 | 2 | 0 | 6 | 1 | 2 | 0 | 58 (41 – 82) | |
| Mixed cell | 12 (0) | 0 | 2 | 10 | 0 | 3 | 1 | 6 | 2 | 60 (40 – 77) | |
| Undifferentiated | 3 (1) | 12 | 0 | 1 | 1 | 1 | 0 | 2 | 0 | 68 (62 – 71) | |
| All types | 116 (5) | 4 | 20 | 86 | 6 | 17 | 10 | 78 | 11 | 61 (38 – 82) | |
1Mixed cell has components of serous subtype cancer cells; 2fallopian tube adenocarcinoma; 3staging information was not available for a women with a serous ovarian carcinoma diagnosed at 91 years of age.