Table 4.
Features of carriers based on BRCA1 and BRCA2 mutation status
| Gene mutated | Histological subtype | Number of mutation carriers (n = 439) (%) | Age of diagnosis, years (%) | Tumour grade (%) | Disease stage 1 (%) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| <60 (n = 196) | ≥60 (n = 243) | G1 (n = 13) | G2 (n = 93) | G3 (n = 312) | Un-classified (n = 21) | I,II (n = 78) | III,IV (n = 360) | |||
| BRCA1 | Serous | 15 | 9 | 6 | 0 | 1 | 14 | 0 | 3 | 12 |
| Endometrioid | 2 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | |
| Mixed cell | 4 | 3 | 1 | 0 | 0 | 4 | 0 | 0 | 4 | |
| Undifferentiated | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| All types | 21 | 14 | 7 | 0 | 1 | 20 | 0 | 3 | 18 | |
| BRCA2 | Serous | 17 | 12 | 5 | 0 | 3 | 13 | 1 | 1 | 16 |
| Endometrioid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Mixed cell | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Undifferentiated | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | |
| All types | 18 | 12 | 6 | 0 | 3 | 14 | 1 | 1 | 17 | |
| BRCA1 or BRCA2 | All types | 39 (8.9) | 26 (13.3) | 13 (5.3) | 0 | 4 (4.3) | 34 (10.9) | 1 (4.8) | 4 (5.1) | 35 (9.7) |
| None | 400 (91.1) | 170 (86.7) | 230 (94.7) | 13 (100) | 89 (95.7) | 278 (89.1) | 20 (95.2) | 74 (94.9) | 325 (90.3) | |
1Staging information was not available for a women found mutation-negative who had a serous ovarian carcinoma diagnosed at 91 years of age.