Table 1.

Characteristics of the clinical studies of brentuximab vedotin in relapsed/refractory HL

Study (yr)	Number (median age, range)	Design	Disease characteristics	Dosage and cycle of brentuximab vedotin
Younes et al29	45 (36, 20–87)	Phase I	Relapsed or refractory CD30-positive HL and ALCL after chemotherapy or auto-SCT.	At a dose of 0.1–3.6 mg/kg of body weight every 3 weeks.
Fanale et al30	44 (33, 18–82)	Phase I	Relapsed/refractory CD30-positive hematologic malignancies, including HL, SALCL, peripheral T-cell lymphoma.	Brentuximab vedotin was administered intravenously on Days 1, 8, and 15, of each 28-day cycle at doses ranging from 0.4 to 1.4 mg/kg.
Ogura et al6	20 (41, 22–88)	Phase I/II	Relapsed or refractory CD30-positive HL or SALCL.	1.8 mg/kg was given to 14 patients (nine with HL and five with SALCL). The median number of treatment cycles was 16 (range, 4–16).
Gopal et al31	25 (32, 20–56)	Phase II	>100 days after allo-SCT, had no active GVHD, and received a median of 9 (range, 5–19) prior regimens.	1.2 (n=6) or 1.8 (n=19) mg/kg every 3 weeks (median, 8 cycles; range, 1–16).
Younes et al32 and Gopal et al33	102 (31, 15–77)	Phase II	Relapsed/refractory HL after auto-SCT.	1.8 mg/kg intravenously once every 3 weeks over 30 minutes on an outpatient basis for up to 16 infusions.

Abbreviations: allo-SCT, allogeneic stem cell transplantation; auto-SCT, autologous stem cell transplantation; GVHD, graft-versus-host disease; HL, Hodgkin’s lymphoma; SALCL, systemic anaplastic large-cell lymphoma.