Table 2.
Comorbidities among patients undergoing elective total hip and knee arthroplasties grouped by their receipt of perioperative fluid resuscitation with hydroxyethyl starch 6% or with albumin 5% or with neither. Values are numbers (percentages) of patients unless stated otherwise
| Hydroxyethyl starch (n=43 732) | Albumin (n=8022) | Neither (n=999 687) | |
|---|---|---|---|
| Median (IQR) Charlson comorbidity index | 0 (0–1) | 0 (0–1) | 0 (0–1) |
| Elixhauser comorbidity grouping: | |||
| Congestive heart failure | 1660 (3.8) | 444 (5.5) | 29 922 (3.0) |
| Valvular disease | 2139 (4.9) | 470 (5.9) | 46 668 (4.7) |
| Pulmonary circulation disease | 498 (1.1) | 143 (1.8) | 11 908 (1.2) |
| Peripheral vascular disease | 1319 (3.0) | 307 (3.8) | 26 275 (2.6) |
| Paralysis | 158 (0.4) | 49 (0.6) | 3298 (0.3) |
| Other neurological disorders | 1966 (4.5) | 403 (5.0) | 40 601 (4.1) |
| Chronic pulmonary disease | 7164 (16.4) | 1453 (18.1) | 158 648 (15.9) |
| Diabetes, no chronic complications | 7743 (17.7) | 1506 (18.8) | 189 618 (19.0) |
| Diabetes, chronic complications* | 751 (1.7) | 160 (2.0) | 16 896 (1.7) |
| Hypothyroidism | 6704 (15.3) | 1389 (17.3) | 157 863 (15.8) |
| Chronic renal failure | 1813 (4.1) | 527 (6.6) | 42 356 (4.2) |
| Hypertension, uncomplicated | 27 400 (62.7) | 4962 (61.9) | 636 421 (63.7) |
| Hypertension, complicated | 2162 (4.9) | 618 (7.7) | 51 440 (5.1) |
| Liver disease | 468 (1.1) | 135 (1.7) | 10 500 (1.1) |
| Chronic peptic ulcer disease* | 30 (0.1) | 4 (0.1) | 496 (0.1) |
| HIV/AIDS | 29 (0.1) | 12 (0.2) | 515 (0.1) |
| Lymphoma | 177 (0.4) | 44 (0.5) | 3126 (0.3) |
| Metastatic cancer | 116 (0.3) | 42 (0.5) | 2161 (0.2) |
| Solid tumor without metastasis | 585 (1.3) | 121 (1.5) | 11 124 (1.1) |
| Rheumatoid arthritis or collagen vascular disease | 2115 (4.8) | 471 (5.9) | 47 774 (4.8) |
| Coagulopathy | 1249 (2.9) | 363 (4.5) | 25 301 (2.5) |
| Obesity* | 10 032 (22.9) | 1806 (22.5) | 225 086 (22.5) |
| Weight loss | 316 (0.7) | 110 (1.4) | 6634 (0.7) |
| Fluid and electrolyte disorder | 4586 (10.5) | 1209 (15.1) | 101 163 (10.1) |
| Chronic blood loss anemia | 1263 (2.9) | 177 (2.2) | 20 766 (2.1) |
| Deficiency anemia | 7421 (17.0) | 1841 (22.9) | 174 430 (17.4) |
| Alcohol misuse | 293 (0.7) | 73 (0.9) | 5410 (0.5) |
| Drug misuse | 197 (0.5) | 58 (0.7) | 6033 (0.6) |
| Psychosis | 970 (2.2) | 204 (2.5) | 20 136 (2.0) |
| Depression | 6614 (15.1) | 1172 (14.6) | 135 137 (13.5) |
| Other: | |||
| Sleep apnea | 5316 (12.2) | 861 (10.7) | 109 957 (11.0) |
IQR=interquartile range.
χ2 test used to compare categorical variables, Kruskal-Wallis test for Charlson comorbidity index. All variables (except diabetes with chronic complications, chronic peptic ulcer disease, and obesity) were significantly associated with the type of fluid resuscitation; at least one of the comparisons between groups was significant (P<0.001).
*No significant differences between groups.