Table 3.
Hemodynamic Parameters
| Day 0 | Day 1 | Day 3 | 1 day after rewarming | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interval from onset (h) Median Interquatile range Variable | 5.8 (1.5–9.3) Hypothermia | 5.9 (2.2–8.3) Fever control | p value | 24 (20–29) Hypothermia | 26 (19–31) Fever control | p value | 71 (65–78) Hypothermia | 72 (67–76) Fever control | p value | 178 (147–219) Hypothermia | 121 (111–130) Fever control | p value |
| Core temperature (°C) | 35.3±1.6 | 36.1±0.9 | 0.002 | 33.4±0.8 | 35.7±1.0 | <0.001 | 33.6±1.0 | 35.6±1.0 | <0.001 | 36.5±0.8 | 36.7±0.8 | 0.113 |
| MAP (mmHg) | 89±19 | 95±23 | 0.135 | 89±15 | 89±15 | 0.960 | 92±16 | 94±18 | 0.458 | 98±15 | 99±14 | 0.832 |
| ICP (mmHg) | 21±19 | 29±23 | 0.088 | 22±24 | 22±17 | 0.969 | 22±24 | 20±15 | 0.602 | 18±15 | 22±16 | 0.188 |
| ≤30 | 48 (74) | 25 (71) | 0.795 | 70 (80) | 37 (84) | 0.612 | 70 (82) | 35 (90) | 0.289 | 65 (89) | 29 (81) | 0.226 |
| >30 | 17 (26) | 10 (29) | 17 (20) | 7 (16) | 15 (18) | 4 (10) | 8 (11) | 7 (19) | ||||
| CPP (mmHg) | 69±27 | 76±31 | 0.296 | 67±27 | 64±27 | 0.611 | 69±33 | 71±28 | 0.817 | 80±23 | 77±23 | 0.413 |
| ≤50 | 12 (19) | 6 (18) | 0.946 | 12 (14) | 9 (20) | 0.326 | 16 (19) | 6 (15) | 0.642 | 8 (11%) | 3 (8) | 0.669 |
| >50 | 52 (81) | 27 (82) | 75 (86) | 35 (80) | 69 (81) | 33 (85) | 65 (89) | 33 (92) | ||||
| CVP (mmHg) | 5.2±3.8 | 7.0±3.7 | 0.059 | 6.6±4.0 | 5.9±3.7 | 0.338 | 7.6±4.8 | 7.3±3.5 | 0.688 | 6.5±3.4 | 7.4±4.9 | 0.278 |
| CI (L/min/m2) | 3.3±1.4 | 3.3±1.1 | 0.824 | 3.1±0.9 | 3.5±1.0 | 0.057 | 3.6±1.0 | 3.8±1.1 | 0.426 | 4.4±1.1 | 4.2±1.8 | 0.380 |
| SvO2 (%) | 73±14 | 76±7 | 0.401 | 76±11 | 78±6 | 0.251 | 79±9 | 79±7 | 0.936 | 78±9 | 78±8 | 0.736 |
| SVRI (dynes/s/cm–5) | 807±390 | 750±458 | 0.578 | 822±298 | 709±256 | 0.038 | 712±284 | 666±242 | 0.390 | 622±214 | 634±384 | 0.849 |
Values are n (%) or mean±standard deviation.
MAP, mean arterial pressure; ICP, intracranial pressure; CPP, cerebral perfusion pressure; CVP, central venus pressure; CI, cardiac index; SvO2, mixed venous oxygen saturation; SVRI, systemic vascular resistance index.