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. Author manuscript; available in PMC: 2015 Mar 27.
Published in final edited form as: Endocr Relat Cancer. 2013 Nov 4;20(6):R341–R356. doi: 10.1530/ERC-13-0364

Figure 5.

Figure 5

When FlnA is localized to the cytoplasm or plasma membrane, it has the ability to promote tumor metastasis through interaction with signaling molecules. If FlnA undergoes proteolysis and the proteolysed fragments localize to the nucleus, where they regulate transcription, then they may act to suppress tumor growth and inhibit metastasis.