Figure 1.

Chronic alcohol ingestion and muscle injury decreased voluntary running distances. Injured or uninjured alcoholic and control mice were provided access to a voluntary running wheel. Voluntary activity was measured by (A) daily and (B) total distance accrued over 14 days. Alcohol-fed mice voluntarily ran ~53% of the distance covered by control-fed mice. In control mice, daily running distances were temporarily reduced following injury (up to day 5 in A); however, total distances in 14 days were similar. In contrast, injured alcohol-fed mice ran significantly less over 14 days compared to uninjured alcoholics. Significance was accepted at p ≤ 0.05. *, compared to control-fed, injured group. #, compared to EtOH-fed, uninjured group.