Table 2.
Identified 30-gene and 25-gene signatures
| Symbol | Entrez gene name | Type(s)^ | Biomarker#^ | Symbol | Entrez gene name | Type(s)^ | Biomarker#^ |
|---|---|---|---|---|---|---|---|
| LSC- 30 genes | LSC+ 25 genes | ||||||
| ANLN | anillin, actin binding protein | other | APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | other | ||
| AURKA | aurora kinase A | kinase | E | ATXN3 | ataxin 3 | peptidase | |
| CCNA1 | cyclin A1 | other | CCND2 | cyclin D2 | other | D, E | |
| CCL5 | chemokine (C-C motif) ligand 5 | cytokine | D, E, U | DYNLL2 | dynein, light chain, LC8-type 2 | other | |
| CD38 | CD38 molecule | enzyme | E, P, U | ERC1 | ELKS/RAB6-interacting/CAST family member 1 | other | |
| CDC25B | cell division cycle 25B | phosphatase | ETV6 | ets variant 6 | transcription regulator | ||
| CDK1 | cyclin-dependent kinase 1 | kinase | GGNBP2 | gametogenetin binding protein 2 | other | ||
| CENPA | centromere protein A | other | GIMAP6 | GTPase, IMAP family member 6 | other | ||
| CLC | Charcot-Leyden crystal galectin | enzyme | KIF1B | kinesin family member 1B | transporter | ||
| CPA3 | carboxypeptidase A3 (mast cell) | peptidase | KIF1C | kinesin family member 1C | other | ||
| CSTA | cystatin A (stefin A) | other | KRAS | Kirsten rat sarcoma viral oncogene homolog | enzyme | D, E, P, R, U | |
| DDX53 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 | other | LOC728392 | uncharacterized LOC728392 | other | ||
| DLGAP5 | discs, large (Drosophila) homologassociated protein 5 | phosphatase | MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | transcription regulator | ||
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | growth factor | D, DP, E, P, U | MPO | myeloperoxidase | enzyme | D, E, U |
| IL36B | interleukin 36, beta | cytokine | MTERFD2 | MTERF domain containing 2 | other | ||
| KIAA0101 | KIAA0101 | other | NAV1 | neuron navigator 1 | enzyme | ||
| LATS2 | large tumor suppressor kinase 2 | kinase | PIAS1 | protein inhibitor of activated STAT, 1 | transcription regulator | U | |
| MBD3 | methyl-CpG binding domain protein 3 | other | PSMB6 | proteasome (prosome, macropain) subunit, beta type, 6 | peptidase | ||
| MND1 | meiotic nuclear divisions 1 homolog (S. cerevisiae) | other | SESN1 | sestrin 1 | other | ||
| MPO | myeloperoxidase | enzyme | D, E, U | SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | transporter | |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | other | STK38 | serine/threonine kinase 38 | kinase | ||
| NDC80 | NDC80 kinetochore complex component | other | TMIE | transmembrane inner ear | other | ||
| OLFM4 | olfactomedin 4 | other | YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | enzyme | ||
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | enzyme | D | ZBTB10 | zinc finger and BTB domain containing 10 | other | |
| RNASE3 | ribonuclease, RNase A family, 3 | enzyme | E | ZNF384 | zinc finger protein 384 | transcription regulator | |
| SKA3 | spindle and kinetochore associated complex subunit 3 | other | |||||
| SPC25 | SPC25, NDC80 kinetochore complex component | other | |||||
| STAR | steroidogenic acute regulatory protein | transporter | |||||
| TOP2A | topoisomerase (DNA) II alpha 170 kDa | enzyme | D, E, P, RT | ||||
| ZWINT | ZW10 interacting kinetochore protein | other | |||||
#: D = diagnosis; DP = disease progression; P = prognosis; E = efficacy; RT = response to therapy; U = unspecified application.
^: Data resource: 2000–2014 Ingenuity Systems, Inc.