Table 3.
Univariate and multivariate analyses of overall survival in patients with all types of AML, for the LSC- DNM gene-sets
| Dataset | Variate model | Variates | HR | 95% CI | p-value |
|---|---|---|---|---|---|
| GSE14468 (n = 518) | Univariate model | 3 DNM fGSs vs 4 control fGSs | 0.7 | 0.55-0.84 | 0.00043*** |
| ELN_RiskFavorable vs. Adverse | 0.3 | 0.20-0.40 | 2.15E-13*** | ||
| complex vs. others | 2.2 | 1.50-3.16 | 0.000024*** | ||
| 7q vs. others | 2.1 | 1.45-2.97 | 0.000051*** | ||
| ELN_RiskIntermediate-II vs. Adverse | 0.5 | 0.36-0.70 | 0.000053*** | ||
| Age group, years (≥60 vs. <60) | 1.7 | 1.29-2.28 | 0.00016*** | ||
| 3q vs. others | 2.1 | 1.32-3.42 | 0.0015** | ||
| ELN_RiskIntermediate-I vs. Adverse | 0.6 | 0.46-0.86 | 0.0035** | ||
| inv16 vs. others | 0.5 | 0.32-0.83 | 0.0057** | ||
| cebpa mutation vs. others | 0.6 | 0.67-0.95 | 0.028* | ||
| Multivariate model | 3 DNM fGSs vs 4 control fGSs | 0.7 | 0.60-0.91 | 0.0050** | |
| Age group, years (≥60 vs. <60) | 1.7 | 1.26-2.29 | 0.00046*** | ||
| ELN_RiskFavorable vs. Adverse | 0.4 | 0.26-0.76 | 0.0034** | ||
| complex vs. others | 1.6 | 0.96-2.58 | 0.07. | ||
| ELN_RiskIntermediate-II vs. Adverse | 0.7 | 0.43-1.23 | 0.23 | ||
| 7q vs. others | 1.3 | 0.82-2.09 | 0.26 | ||
| 3q vs. others | 1.3 | 0.71-2.27 | 0.42 | ||
| inv16 vs. others | 0.8 | 0.47-1.39 | 0.44 | ||
| cebpa mutation vs. others | 0.9 | 0.53-1.45 | 0.61 | ||
| ELN_RiskIntermediate-I vs. Adver | 0.9 | 0.53-1.48 | 0.65 | ||
| TCGA (n = 197) | Univariate model | 3 DNM fGSs vs 4 control fGSs | 0.46 | 0.32-0.64 | 4.66E-06*** |
| Age group, years (≥60 vs. <60) | 3.02 | 2.16-4.21 | 9.94E-12*** | ||
| gender | 0.88 | 0.64-1.22 | 0.44 | ||
| normal_karyotype vs. others | 1.12 | 0.81-1.55 | 0.50 | ||
| BM Blast(>50 vs. <=50) | 0.88 | 0.60-1.30 | 0.53 | ||
| Multivariate mode | 3 DNM fGSs vs 4 control fGSs | 0.60 | 0.42-0.86 | 0.0058** | |
| Age group, years (≥60 vs. <60) | 2.59 | 1.83-3.67 | 8.8E-08*** | ||
| GSE12417 (n = 242) | Univariate model | 3 DNM fGSs vs 4 control fGSs | 0.60 | 0.43-0.83 | 0.0021** |
| Age group, years (≥60 vs. <60) | 1.63 | 1.18-2.26 | 0.0029** | ||
| Multivariate model | 3 DNM fGSs vs 4 control fGSs | 0.60 | 0.43-0.83 | 0.0021** | |
| Age group, years (≥60 vs. <60) | 1.49 | 1.07-2.07 | 0.018* |
Significance code: ‘.’:p < .1; ‘*’: p < .05; ‘**’p < .01; ‘***’p < .001.
Significant univariate tested factors (p < .05) are used for multivariate test. Boldface highlights the results of DMN fGSs.