Fig 6. Predicted reaction scheme of PMA induction of Luciferase activity from synthetic reporter (AP1LUC) by AP1 that is repressed by steroid-bound receptor (GR).

The position of the CLS, and positions of action of TIF2, NU6027, phenanthroline, and GR, as determined by the data of Figs. 3–5, are indicated. A’ and A” represent unknown, post-CLS steps, each of which can lead to Luciferase activity but the efficiency from A” is much less than A’.