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. 2015 Mar 27;10(3):e0120982. doi: 10.1371/journal.pone.0120982

Fig 5. INF7 mediates release of endosomal SR into the cytosol.

Fig 5

Liposomes containing SR with or without INF7 were incubated with CV1 cells for 1 hr, washed to remove un-endocytosed liposomes, and allowed to incubate without liposomes for an additional 2 hr. SR remains confined in endosomes without INF7 (-INF7), but after release into the cytosol by INF7, SR is rapidly transported from the cytosol into the extracellular volume (+INF7) leading to much dimmer fluorescence in cells incubated INF7-containing liposomes. See main text for more detailed mechanistic explanation.