Table 3. Alterations of genes in 288 breast invasive ductal carcinomas.

	Positive rate	Yes	No	Failure
KRAS mutation	1.8% (5/278)	5	273	10
AKT1 mutation	4.4% (11/252)	11	241	36
PIK3CA mutation	15.6% (39/250)	39†	211§	38¶
PIK3CA exon 4 mutation	1.4% (3/216)	3	213	72
PIK3CA exon 9 mutation	4.7% (10/214)	10	204	74
PIK3CA exon 20 mutation	12.3% (27/219)	27	192	69
PTEN loss*	35.3% (98/278)	98	180	10
PAM activation	50.7% (146/288)	146‡	142	-

†, PIK3CA mutation with any exon

§, no mutation in any exon

¶, Amplification failure of 3 exons

*, PTEN loss by immunohistochemistry

‡, Alteration in any molecule of PIK3CA, AKT1, KRAS or PTEN.