Table 3. Alterations of genes in 288 breast invasive ductal carcinomas.
Positive rate | Yes | No | Failure | |
---|---|---|---|---|
KRAS mutation | 1.8% (5/278) | 5 | 273 | 10 |
AKT1 mutation | 4.4% (11/252) | 11 | 241 | 36 |
PIK3CA mutation | 15.6% (39/250) | 39† | 211§ | 38¶ |
PIK3CA exon 4 mutation | 1.4% (3/216) | 3 | 213 | 72 |
PIK3CA exon 9 mutation | 4.7% (10/214) | 10 | 204 | 74 |
PIK3CA exon 20 mutation | 12.3% (27/219) | 27 | 192 | 69 |
PTEN loss* | 35.3% (98/278) | 98 | 180 | 10 |
PAM activation | 50.7% (146/288) | 146‡ | 142 | - |
†, PIK3CA mutation with any exon
§, no mutation in any exon
¶, Amplification failure of 3 exons
*, PTEN loss by immunohistochemistry
‡, Alteration in any molecule of PIK3CA, AKT1, KRAS or PTEN.