Figure 4.

Contribution of non-cardiac Na⁺ channel isoforms to I_NaT in LV cardiomyocytes of dogs with HF

A, consecutive raw I_NaT traces recorded before (control) and during MTSEA application in freshly isolated cells. B, time course of MTSEA effect on the peak I_NaT recorded in the same cell as shown in A. C, summary data and statistical analysis of I_NaT density in freshly isolated control and MTSEA-treated cells and infected cells with virus containing non-silencing siRNA or Na_v1.5-siRNA. Statistically significant changes, P < 0.05, were found in both groups evaluated by the ANOVA test followed by Bonferroni's post hoc test (*,** Na_v1.5-siRNA vs. freshly isolated control and GFP control, respectively, § MTSEA vs. freshly isolated control) I_NaT was recorded at –10 mV. Data are mean ± SEM.