Skip to main content
. 2015 Mar 13;593(Pt 6):1429–1442. doi: 10.1113/jphysiol.2014.279554

Figure 3.

Figure 3

GS-458967 (that specifically targets endogenous late INa) causes dose-dependent shortening of the experimental and computed APD in guinea pig ventricular myocytes

A, simulated effects of GS-458967 on guinea pig APD. B, the timecourse of INa during the AP. C, experimentally measured and model-predicted GS-458967-induced concentration-dependent reduction in APD. D, experimentally measured and model-predicted effects of GS-458967 on the amplitude of late INa.