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GS-458967 (that specifically targets endogenous late INa) causes dose-dependent shortening of the experimental and computed APD in guinea pig ventricular myocytes
A, simulated effects of GS-458967 on guinea pig APD. B, the timecourse of INa during the AP. C, experimentally measured and model-predicted GS-458967-induced concentration-dependent reduction in APD. D, experimentally measured and model-predicted effects of GS-458967 on the amplitude of late INa.
