Figure 5.

Systematic comparison of sensitivity of simulated guinea pig cardiac ventricular action potentials to small perturbations before and after application the selective blocker of I_NaL GS-458967

A small inward current (between 0.1 and 0.2 pA pF⁻¹ for 50 ms) was applied randomly during the AP plateau between 30 and 200 ms after AP initiation for no I_NaL block (A), and I_NaL block via 0.1 μm GS-458967 (B) and 1.0 μm GS-458967 (C). Lower panels show the timecourse and amplitude of the associated APD₉₀ variability.