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. 2015 Feb 20;106(3):299–306. doi: 10.1111/cas.12604

Figure 5.

Figure 5

Heme oxygenase-1 (HO-1) impacts chemoattractant-induced migration of myeloid cells. (a) Migration responses of wild type (WT) and HO-1+/− CD11b+ cells toward S100A8 (10 pg/mL), vascular endothelial growth factor (VEGF) (10 ng/mL), or monocyte chemoattractant protein-1 (MCP-1) (10 ng/mL). Data are mean ± SE of three independent experiments. *P < 0.05 versus control group of same genotype; †P < 0.05 versus WT group. (b) Migration response of HO-1+/− CD11b+ cells toward S100A8 in the absence or presence of 10 μM of CORM-2 or inactive CORM-2 (iCORM-2). Data are mean ± SE of three independent experiments. *P < 0.05 versus control. (c) WT and HO-1+/− bone marrow-derived macrophages were treated with 10 pg/mL of S100A8 for indicated times. The levels of phospho-p38 and total p38 examined by western blot analysis.