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. 2015 Feb 17;106(3):315–323. doi: 10.1111/cas.12601

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Folliculin (FLCN) expression in Birt–Hogg–Dubé (BHD) and sporadic tumors. (a) Representative results of Western blot analysis of BHD kidneys. Patients BHD9 and BHD17 had two independent tumors (T1, T2). The FLCN bands (70 kDa) were clearly detected in non-tumor lanes but barely seen in tumor lanes. N, normal-looking region; T, tumor region. (b) Representative results of Western blotting analysis of sporadic renal tumors and normal kidneys without the background of BHD. Sporadic renal tumors include clear cell renal cell carcinomas (RCCs) (n = 3), oncocytoma (n = 1), papillary RCC (n = 1), and chromophobe RCCs (n = 3).