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. 2015 Jan 23;172(7):1859–1868. doi: 10.1111/bph.13032

Figure 7.

Figure 7

NHT of HDC+/+ and HDC−/− mice: effect of TA1 administration. HDC+/+ were treated i.p. with saline (Veh) or TA1 (1.32, 4 and 11 μg·kg−1). After 15 min, their threshold to noxious heat (from 46.5°C to 49.5°C) was measured as described in Methods (A). In another set of experiments mice were pretreated with 10 mg·kg−1 pyrilamine (i.p.) or Veh (i.p.) 15 min before, 1.32 and 4 μg·kg−1 TA1 i.p. (B). HDC−/− mice were treated i.p. with saline (Veh) or with TA1 (1.32 μg·kg−1) to measure their NHT as described in Methods (C). Results are the means ± SEM of observations from 10 mice. *P < 0.05 versus Veh; **P < 0.01 versus Veh; #P < 0.05 and ##P < 0.01 versus TA1 without pyrilamine respectively. Results are the means ± SEM of observation from 10 mice.