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. 2015 Feb 10;172(7):1869–1881. doi: 10.1111/bph.13031

Figure 3.

Figure 3

Effect of UFP-512 on Nrf2-targeted gene expression in normoxia. The mRNA expression of Nrf2-dependent genes NQO1, HO-1, GCLC and GCLM was assessed by quantitative real-time PCR in the HEK293t cells after treatment with UFP-512 (U), naltrindole (N) or UFP-512 plus naltrindole (U + N). *P < 0.05, **P < 0 0.01, ***P < 0.005, significantly different from control (C). ##P < 0.01, ###P < 0.005, significantly different from UFP-512 alone. Note that all the genes studied significantly increased or tended to increase their mRNA expression after UFP-512 treatment and that addition of the DOR antagonist naltrindole fully blocked the effects of UFP-512.