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. 2015 Apr 1;25(2):78–84. doi: 10.1089/nat.2014.0517

FIG. 1.

FIG. 1.

(A) Binding of fluorescent G4T4G4 peptide nucleic acids (PNA) to G4T4G4 and C4A4C4 DNA oligonucleotides. G4T4G4 PNA (1μM) was incubated with varying concentrations (shown on the top of the lanes in μM) of DNA oligonucleotides. Lanes 1 to 6 contain samples with G4T4G4 DNA oligonucleotides; lanes 7 to 10 contain samples with C4A4C4 DNA oligonucleotides; lanes 1 and 7 are samples with no PNA added. (B) Binding of fluorescent G4T4G4 PNA to ppG4T4ppG4 and C4A4C4 DNA oligonucleotides. G4T4G4 PNA (1μM) was incubated with varying concentrations (shown on the top of the lanes in μM) of DNA oligonucleotides. Lanes 1 to 5 contain samples with ppG4T4ppG4 DNA oligonucleotides; lanes 6 to 10 contain samples with C4A4C4 DNA oligonucleotides. Lanes 1, 6, and 9 are samples with no PNA added. (C) Chemical structure of 8-aza-7-deazaguanine (ppG).