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. Author manuscript; available in PMC: 2015 Sep 12.
Published in final edited form as: Nature. 2015 Feb 25;519(7542):187–192. doi: 10.1038/nature14259

Extended Data Figure 7. Relation of Notum to other Esterases of the α/β hydrolase family.

Extended Data Figure 7

a, Comparison between hNotum and human Esterase D, showing structural relatedness. hNotum is also related to APT1, a cytosolic esterase used in this study as a positive control for fatty acid esterase activity. In the views shown here, the hNotum structure has been rotated by 90° around the x-axis relative to the structure shown in Figure 3b. b, Rootless phylogenetic tree of animal Notum proteins (red) and plant pectinacetylesterases (PAE, green). Extent of sequence identity to hNotum is shown next to species name. Percentages between branches indicate sequence identity between neighbours.