Table 4.
Reasons for protocol deviation (n = 179)
| Reason | Patients experiencing deviation, n (%) | Number of deviations | |
|---|---|---|---|
| Total frequency (%) | Median (IQR) deviation/patient | ||
| Permissible | |||
| Toxicities | 91 (46.0) | 209 (23.3) | 2 (1 to 3) |
| Co-morbidities | 66 (33.3) | 179 (20.0) | 2 (1 to 4) |
| Non-permissible | |||
| Patient-related | 107 (54.0) | 221 (24.7) | 2 (1 to 2) |
| Physician-related | 103 (52.0) | 221 (24.7) | 2 (1 to 3) |
| Other | 35 (17.7) | 66 (7.3) | 1 (1 to 2) |
| Total | 179 (90.4) | 896 (100.0) | 4 (2 to 7) |
As more than one reason can contribute to a deviation, the total number of patients experiencing deviation is less than the total number of deviations.