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. 2015 Mar 22;15:144. doi: 10.1186/s12879-015-0887-y

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© Gerardin et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Pharmacokinetics and pharmacodynamics of antimalarial drugs are implemented in an agent-based model of malaria transmission and calibrated to clinical data. (A) A simplified model of drug pharmacokinetics uses a double exponential to model antimalarial drug distribution and elimination. (B) Pharmacokinetics of 5 antimalarials as simulated with the simple PK model in a 50 kg adult. (C) Maximum drug concentration with simple PK including age-based dosing, weight-dependent PK parameters, and WHO/CDC age-weight tables. See Tables 1 and 2 for model PK parameters and age-based dose fractions.