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. 2015 Jan 24;18(5):pyu041. doi: 10.1093/ijnp/pyu041

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Experimental design. The animals received daily i.p. injections of saline (SAL) or MK-801 (1mg/kg) for 28 days. CBD (15, 30, and 60mg/kg) or vehicle (VEH) treatment began on the 6th day after the start of MK-801 administration and continued until the end of the treatment. One day later, animals were submitted to the prepulse inhibition (PPI) test. Immediately after the PPI, their brains were removed and processed to assess immunohistochemical changes in FosB/ΔFosB and parvalbumin (PV) expression and changes in mRNA expression of the NMDAR GluN1 subunit gene by RT-PCR. CBD effects were compared to those induced by the atypical antipsychotic clozapine (CLZ; 1mg/kg).