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. 2015 Jan 31;18(5):pyu093. doi: 10.1093/ijnp/pyu093

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Effects of morphine-N-(ε-trifluoroacetylcaproyloxy) succinimide ester (TFCS)-keyhole limpet hemocyanin (KLH) immunization on morphine-induced locomotor sensitization. (a) Experimental timeline. (b) Initiation of morphine-induced locomotor sensitization. During 14 daily injections of morphine (10mg/kg, s.c.), locomotor activity significantly increased on days 7 and 14 of initiation, with no difference between groups. Locomotor activity on day 0 served as baseline. (c) Locomotor activity in morphine-TFCS-KLH-treated rats was significantly lower compared with KLH-treated rats after the morphine challenge on day 10. (d) Locomotor activity in morphine-TFCS-KLH–treated rats was significantly lower compared with KLH-treated rats after the morphine challenge on day 14. The data are expressed as mean ± SEM. *P < .05, compared with KLH group; **P < .01, compared with KLH group (n=10 per group).