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. 2015 Jan 31;18(5):pyu093. doi: 10.1093/ijnp/pyu093

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Effects of morphine-N-(ε-trifluoroacetylcaproyloxy) succinimide ester (TFCS)-keyhole limpet hemocyanin (KLH) immunization on heroin-induced reinstatement. (a) Experimental timeline. (b) Active nosepokes during acquisition, extinction, and reinstatement of heroin self-administration. The numbers of active nosepokes during acquisition and extinction were not significantly different between groups. Heroin-primed (0.5mg/kg) reinstatement was significantly inhibited in the morphine-TFCS-KLH group (n=11) compared with the KLH group (n=12) on days 10, 14, and 25 after the last immunization. (c) Inactive nosepokes during acquisition, extinction, and reinstatement were not significantly different between groups. The data are expressed as mean ± SEM. ***P < .001, compared with KLH group.