Table 1.

Characterization of Clock Gene Expression in the Mouse BLA. (a) Comparison of cosinor analysis of the cyclic expression of 18 clock genes in basolateral amygdala (BLA) tissue between control (total of n = 49) and anhedonic (total of n = 30) mice). P values <.05 denote a statistically significant cosinor analysis fitted curve, indicating diurnally rhythmic gene expression. (b) Peak time, trough and amplitude of clock genes exhibiting diurnally rhythmic gene expression in the mouse BLA. (c) Comparison of BLA and suprachiasmatic nucleus (SCN) expression pattern of clock genes.

1a
	Cosinor Analysis P Value
Gene	Control	Anhedonic
Clock	.004	.63
Bmal1	.005	.01
Cry1	.07	.97
Cry2	.008	.52
Per1	.04	.22
Per2	.82	.53
Per3	.0005	.92
Id2	.005	.06
Rev-erbα	.03	.93
Rev-erbβ	.63	.94
Ror-α	.3	.51
Ror-β	.007	.19
Ror-γ	.03	.38
Dec1	.22	.31
Dec2	.12	.75
E4bp4	.13	.09
Npas2	.34	.35
NeuroD1	.2	.84

1b
Gene	Peak (ZT)	Trough (ZT)	Amplitude
Clock	4	16	1.42
Bmal1	16/23 (anhedonic)	4/11 (anhedonic)	0.67/0.42 (anhedonic)
Cry2	21	9	0.48
Per1	3	15	1.32
Per3	4	16	1.81
Id2	18	6	0.34
Rev-erbα	3	15	1.04
Ror-β	4	16	0.85
Ror-γ	21	9	1.47
Abbreviation: ZT, Zeitgeber Time.

1c
Peak (ZT) mRNA expression
Gene	BLA	SCN
Clock	4	Constitutive	(Zheng et al., 1999; Shearman et al., 2000)
Bmal1	16	16–18	(Shearman et al., 2000)
Cry2	21	—/15	controversial (Kume et al., 1999; Mendoza et al., 2005)
Per1	3	4	(Shearman et al., 1997; Zheng et al., 1999)
Per3	4	6–9	(Zylka et al., 1998; Shearman et al., 2000)
Id2	18	18	(Ueda et al., 2002)
Rev-erbα	3	4	(Onishi et al., 2002)
Ror-β	4	4	(Sumi et al., 2002)
Ror-γ	21	—	not expressed in SCN (Ueda et al., 2002)

Abbreviation: ZT, Zeitgeber Time.