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. 2015 Mar 4;18(5):pyu110. doi: 10.1093/ijnp/pyu110

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Effects of acute GLYX-13 administration on depressive-like behaviors induced by chronic unpredictable mild stress (CUMS) in mice. (a) Behavioral test procedure. Briefly, the mice were subjected to different stressors for 21 consecutive days. On day 22, the open field test (OFT) was conducted 30 minutes after a single injection of vehicle or GLYX-13 (0.5, 5, and 10mg/kg, i.p.). The forced swim test (FST) was performed 30 minutes after the OFT. (b) Acute GLYX-13 (5 and 10mg/kg, i.p.) treatment significantly reversed the depressive-like behaviors induced by CUMS in the FST. (c) GLYX-13 treatment (5 and 10mg/kg, i.p.) significantly reversed the decrease of line crossings (both f P<.01) and rearings (both P<.01) induced by CUMS. However, 3 doses of GLYX-13 had no significant effect on line crossings (all P > .05) and rearings (all P > .05) compared with each other. The data are expressed as mean±SEM (n=9 per group). **P<.01, compared with nonstress treated mice with vehicle-administrated group; ##P<.01, compared with stress treated mice with GLYX-13-administrated group.