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. 2015 Mar 4;18(5):pyu110. doi: 10.1093/ijnp/pyu110

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — PI3K/AKT/mTOR/VGF activity mediates the antidepressant-like effects of GLYX-13 in mice. (a) Experimental procedure for the assessment of the role of PI3K/AKT/mTOR/VGF signaling in the effects of GLYX-13 (10mg/kg, i.p.). Cannula implantations were microinfused into bilateral hippocampus of mice following 7-day acclimatization. Mice were treated with LY294002 (10 nmol/side) and 30 minutes later followed by GLYX-13 (100mg/kg, i.p.) treatment. Then the open field test (OFT) was conducted 30 minutes later and the forced swim test (FST) was conducted 30 minutes after the OFT. (b) Immobility time of mice was measured. Pretreatment with LY294002 reversed the reduction of immobility time produced by GLYX-13. (c-d) All the treatments had no effects on locomotor activity, reflected by the line crossings (c) and rearings (d) in mice. The data are expressed as mean±SEM (n=9 per group). **P<.01, compared with ACSF + Vehicle group; ##P<.01, compared with ACSF + GLYX-13 group.