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. 2015 Mar 4;18(5):pyu110. doi: 10.1093/ijnp/pyu110

Figure 8.

Figure 8.

Administration of the AMPA receptor inhibitor NBQX or mTOR inhibitor rapamycin attenuates the rapid-acting antidepressant-like effectst of GLYX-13 in mice. Experimental procedure for the assessment of the role of AMPA receptor (a) or mTOR (e) in the antidepressant-like effects of GLYX-13 (10mg/kg, i.p.). Cannula implantations were microinfused into bilateral hippocampus of mice following 7-day acclimatization. Mice were treated with NBQX (2 μg/side) or rapamycin (2 nmol/side) and 30 minutes later followed by GLYX-13 (100mg/kg, i.p.). Then the open field test (OFT) was performed 30 minutes later and the FST was conducted 30 minutes after the OFT. (b, f) Immobility time of mice was measured. Pretreatment with NBQX (b) or rapamycin (f) reversed the reduction of immobility time produced by GLYX-13. All the treatments had no effects on locomotor activity, reflected by the line crossings (c, g) and rearings (d, h) in mice. The data are expressed as mean±SEM (n=9 per group). **P<.01, compared with ACSF+Vehicle group; ##P<.01, compared with ACSF + GLYX-13 group.