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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Bone Miner Res. 2015 Apr;30(4):733–741. doi: 10.1002/jbmr.2385

Figure 6. Appendicular defects in Acvr1fx/fx;Bmpr1b−/−;Col2a1-Cre (Acvr1CKO/Bmpr1b−/−) mice.

Figure 6

Cleared skeletal preparations from E17.5 autopods of forelimbs (A-D) and hindlimbs (E-H) stained with alcian blue/nuclear fast red. A blue filter was applied in Photoshop to the images to enhance visualization of alcian blue-stained regions. Arrows in B and F point to reduced or absent ossification in phalangeal elements in Acvr1CKO mice. Arrow in H highlights absence of ossification in the Acvr1CKO/Bmprb−/− hindlimb compared to the Acvr1CKO and Bmpr1b−/− single mutant strains.