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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Bone Miner Res. 2015 Apr;30(4):723–732. doi: 10.1002/jbmr.2378

Figure 5. Working model for osteonectin 3’ UTR SNP mediated effect on bone.

Figure 5

In haplotype A knock-in mice, osteonectin levels in bone are lower compared to haplotype B knock-in mice. The osteonectin 3’ UTR haplotype A is targeted by miRNA (miR-433), which may contribute to lower osteonectin and lower bone volume.