Table 3.
MicroCT analyses of trabecular and cortical bone parameters in femur of vehicle and PTH injected ONA/A and ONB/B mice.
| Trabecular parameters | AA | BB | ||
|---|---|---|---|---|
| Vehicle | PTH | Vehicle | PTH | |
| BVF (%) | 12.00±0.01 | 14.00±0.01 | 12.00±0.01 | 16.00±0.01 |
| Tb.Th.(μm) | 47.03±1.16 | 59.54±1.94# | 46.40±2.54 | 61.65±3.81# |
| Tb.N.(/mm) | 4.43±0.04 | 4.10±0.16 # | 4.72±0.16 | 4.25±0.21 |
| Cortical parameters | AA | BB | ||
|---|---|---|---|---|
| Vehicle | PTH | Vehicle | PTH | |
| Tt.Ar. (mm2) | 2.15±0.07 | 2.17±0.08 | 2.00±0.05 | 2.36±0.06 # |
| Ma.Ar. (mm2) | 1.22±0.06 | 1.15±0.05 | 1.10±0.03 | 1.21±0.07 |
| Ct.Ar. (mm2) | 0.93±0.02 | 1.02±0.02 # | 0.90±0.02 | 1.09±0.02 # |
14-week old male haplotype A and B knock-in mice had been injected for 4 weeks with 40 [μg/kg/day PTH or vehicle. Trabecular bone volume fraction (BVF), trabecular bone number (Tb.N) trabecular bone spacing (Tb.Sp.) and trabecular number (Tb.N.). Total (periosteal) area (Tt.Ar.), marrow area (Ma.Ar.), cortical area (Ct. Ar.). (N=4-6 mice per group) Mean ± SEM.
#
p<0.05 different from corresponding vehicle injected mice of the same genotype.