Table 4.
Histomorphometric analysis of femoral trabecular bone of vehicle and PTH injected ONA/A and ONB/B mice.
| Histomorphometry | AA | BB | ||
|---|---|---|---|---|
| Formation | Vehicle | PTH | Vehicle | PTH |
| Osteoblast number (N.Ob/B.Pm, /mm2) | 1.64±0.26 | 6.28±1.16# | 0.91±0.23* | 6.39±1.52# |
| Mineralizing surface (MS/BS, %) | 4.77±0.55 | 10.58±1.63# | 7.34±0.90* | 8.86±1.16 |
| Bone formation rate (μm3/μm2/ day) | 93.29±1.17 | 317.27±35.02# | 168.36±21.90* | 196.81±21.34 |
| AA | BB | |||
|---|---|---|---|---|
| Resorption | Vehicle | PTH | Vehicle | PTH |
| Osteoclast number (N.Oc/B.Pm; /mm2) | 0.91±0.22 | 0.81±0.25 | 0.72±0.07 | 0.80±0.21 |
| Osteoclast surface (Oc.S/BS, %) | 2.54±0.64 | 2.27±0.66 | 1.97±0.21 | 2.26±0.10 |
| Eroded surface (ES/BS, %) | 5.67±1.14 | 5.63±1.05 | 4.76±0.53 | 5.29±0.38 |
14-week old haplotype A and B knock-in mice had been injected for 4 weeks with 40 μg/kg/day PTH or vehicle (N = 4-6 mice per group)
#
p±0.05 different from the corresponding vehicle injected mice of the same genotype. Mean ± SEM.
*
p<0.05 different from haplotype A mice in the same treatment group.