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. 2015 Mar 27;10(3):e0121512. doi: 10.1371/journal.pone.0121512

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© 2015 Salo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — In experiment I (A), II (B) and IV (C), the development of joint swelling was monitored by measuring the medio-lateral diameter of the hind tibiotarsal joints once a week. Each curve represents the mean of the study group. Asterisks denote significant difference from uninfected mice (P ≤ 0.05). Paraffin-embedded tissue sections were prepared from ΔdbpAB/dbpAB (D; group 7) and ΔdbpAB (E; group 8) infected and uninfected control (F; group 6) mice at 15 weeks of infection and stained for HE. Arrowheads indicate the synovial membrane, and asterisks indicate articular cartilage surface in panels D and E. The original magnification in panels D and E is ×400 and in panel F ×20. Panel F indicates the anatomical structure shown in panels D and E. “Cef” Ceftriaxone treatment, “aTα” anti-TNF-alpha treatment.