Table 2. Effects of EPI against adult S. mansoni BH strain (45 days post infection).

Sample	Dose	Mean worm burden ± SEM (liver and porto-mesenteric)				Reduction in total worm burden
		Male	Female	Couples	Total Worms
Control	0 (PBS only)	12.9±1.1	9.9±1.2	13.7±0.9	50.2±2.4	-
EPI	40 mg/kg	2.6±0.6***	2.2±0.7***	5.3±0.9***	15.2±2.5***	70.0%
EPI	100 mg/kg	7.1±1.0**	6.8±1.3*	8.7±0.7**	31.4±2.7***	39.0%
EPI	300 mg/kg	12.1±1.1	3.0±0.3***	6.1±08***	27.4±1.7***	46.7%

Values are presented as mean± SEM. Number of animals/group = 10. Group treated with 100 mg /kg 3 animals died.

Asterisks indicate that difference compared to the control was significant with *** P<0.001, **P<0.01 and *P<0.05.