Table 1. Percent inhibition of enzymes by TAK-063 at 10 μM.
| Enzyme | % inhibition |
|---|---|
| Acetylcholinesterase | 3 |
| ATPase, Ca2+, Skeletal Muscle | 6 |
| ATPase, Na+/K+, Heart | 8 |
| Carbonic anhydrase II | 6 |
| Cyclooxygenase-1 (COX-1) | 26 |
| Cyclooxygenase-2 (COX-2) | 6 |
| EGF receptor tyrosine kinase | 5 |
| HMG-CoA reductase | 11 |
| 5-Lipoxygenase (5-LO) | 3 |
| Monoamine oxidase A (MAO-A) | 16 |
| Monoamine oxidase B (MAO-B) | 10 |
| Nitric oxide synthase, inducible (iNOS) | 1 |
| Nitric oxide synthase, neuronal (nNOS) | 12 |
| Peptidase, factor Xa | 1 |
| Matrix metalloproteinase-1 (MMP-1) | 9 |
| Matrix metalloproteinase-7 (MMP-7) | 7 |
| Matrix metalloproteinase-13 (MMP-13) | 11 |
| Phosphodiesterase PDE3 | 23 |
| Phosphodiesterase PDE4 | 50 |
| Phosphodiesterase PDE5 | 44 |
| Phosphodiesterase PDE6 | 20 |
| Phosphodiesterase PDE10A1 | 101 |
| Protein kinase A (PKA), nonselective | −3 |
| Protein kinase C (PKC), nonselective | 7 |
| Steroid 5α-reductase | 16 |
| Xanthine oxidase | −3 |
EGF, epidermal growth factor; HMG CoA, 3-hydroxy-3-methyl-glutaryl coenzyme A. Negative value of percent inhibition indicates activation of enzyme activity.