Table 2. Top twenty genes with most significant local associations.
| SNP | Gene | CHR | A1 | A2 | MAF | Beta | Adjust P | R2 |
|---|---|---|---|---|---|---|---|---|
| rs6877400 | SCGB3A1 | 5 | G | A | 0.10 | 1.87 | 6.07E-44 | 0.871 |
| rs2836 | RIPK5 | 1 | C | A | 0.27 | -0.69 | 6.07E-44 | 0.794 |
| rs8458 | VAV3 | 1 | G | A | 0.47 | 1.31 | 2.95E-41 | 0.757 |
| rs14139 | IPO8 | 12 | A | G | 0.50 | 0.74 | 2.93E-40 | 0.684 |
| rs11539046 | RPL14 | 3 | G | A | 0.29 | 2.01 | 4.21E-40 | 0.802 |
| rs3773922 | TFG | 3 | A | G | 0.44 | -0.79 | 1.37E-39 | 0.775 |
| rs7143764 | CHURC1 | 14 | G | A | 0.29 | 1.24 | 3.67E-39 | 0.705 |
| rs10044354 | ERAP2 | 5 | A | G | 0.35 | 1.15 | 2.91E-38 | 0.840 |
| rs13290413 | LOC253039 | 9 | C | A | 0.47 | 0.92 | 3.43E-38 | 0.771 |
| rs10843881 | DDX11 | 12 | A | G | 0.39 | 0.49 | 1.00E-37 | 0.822 |
| rs10876864 | RPS26 | 12 | A | G | 0.47 | -1.10 | 3.03E-36 | 0.769 |
| rs10088428 | HMBOX1 | 8 | A | G | 0.28 | -0.74 | 7.55E-36 | 0.733 |
| rs6464103 | TMEM176A | 7 | G | A | 0.26 | 1.14 | 8.66E-35 | 0.714 |
| rs323719 | CCDC23 | 1 | A | G | 0.19 | 0.80 | 1.49E-34 | 0.704 |
| rs2340518 | DPRXP4 | 17 | G | A | 0.16 | 0.87 | 3.64E-34 | 0.750 |
| rs104664 | FAM118A | 22 | G | A | 0.14 | 1.15 | 6.42E-34 | 0.796 |
| rs4731533 | IRF5 | 7 | A | G | 0.50 | 0.97 | 9.90E-34 | 0.757 |
| rs2395943 | PEX6 | 6 | A | G | 0.34 | -0.77 | 1.02E-33 | 0.749 |
| rs2056613 | WDR48 | 3 | C | A | 0.43 | -0.41 | 1.05E-33 | 0.613 |
| rs1541533 | SNORD14A | 11 | G | A | 0.08 | 0.82 | 2.80E-33 | 0.660 |
For each gene, the most significant SNP was reported. Beta is the increase (+) or decrease (-) unit of transcript per unit increase of reference allele (A1). Reported p-value is adjusted by FDR. R2 is the proportion of expression variability explained by the reported SNP.