Table 3. Classification of genes that are induced or repressed following pathogenic BmCPV infection: comparison among different relevant studies.
| Genes | SH (p50) [ 17 ] | MA (p50) [ 18 ] | DS (4008) [ 15 ] | DS (4008) [ 16 ] | DS (p50) [ 16 ] | D (DaiSzo) our study |
|---|---|---|---|---|---|---|
| digestive enzymes (proteases, lipases, nucleases) | ||||||
| Acidic lipase | ← | |||||
| Alkaline nuclease | → | |||||
| Chymotrypsin-like | ← | ← | ||||
| Hemocyte protease-2 | → | |||||
| Insect intestinal lipase-6 | ← | |||||
| Lipase-1 | → | ← | ← | |||
| Pancreatic lipase-like | → | |||||
| Serine protease | ← | |||||
| Trypsin-like | ← | ← | ||||
| Zinc carboxypeptidase A1 | ← | |||||
| detoxification/metabolism | ||||||
| Antennal esterase CXE14 | ← | |||||
| Aquaporin | → | |||||
| Cytochrome P450 | → | |||||
| Dicarbonyl/L-xylulose reductase | ← | |||||
| Esterase FE4 | ← | |||||
| Farnesyl diphosphate synthase | → | |||||
| Fatty acid binding protein | ← | |||||
| Similar to carboxylesterase | ← | |||||
| Sugar transporter | ← | |||||
| Putative galactose UDP 4-epimerase | → | |||||
| stress response | ||||||
| eIF-4E-1 | → | |||||
| HSP 20.8 | → | |||||
| HSP 23.7 | → | |||||
| HSP25.4 | → | |||||
| signaling | ||||||
| Calreticulin | → | |||||
| Coiled-coil & C2 domain-containing 2A | → | |||||
| Ecdysteroid-22 kinase | → | |||||
| Famesoic acid O-methyltransferase | → | |||||
| FK506-binding protein precursor | → | |||||
| GTP:AMP phosphotransferase | ← | |||||
| GTP-binding protein RAB2 | → | |||||
| Inorganic phosphate transporter 1 | ← | |||||
| Juvenile hormone diol kinase | → | → | ||||
| Neuropeptide-like 4E (NPLP4E) | ← | |||||
| Palmityl transferase (P260) | ← | ← | ||||
| Protein kinase C inhibitor | → | |||||
| Troponin-C | → | |||||
| immune response | ||||||
| Antitrypsin precursor | ← | |||||
| Insulin-binding protein 2 | → | → | → | |||
| Peptidoglycan recognition protein LB-like | → | |||||
| Serpin-5 | → | |||||
| Serpin-28 | → | |||||
| Thioredoxin-like | → | |||||
| Tumor necrosis factor 13 (TNFSF13) | → | |||||
| RNAi | ||||||
| Argonaute-2 | → | |||||
| Dicer-2 | → | |||||
| apoptosis | ||||||
| Carboxypeptidase B | → | |||||
| Caspase-8 | → | |||||
| Inhibitor-of-apoptosis | ← | |||||
| Programmed cell death protein 5 | → | |||||
| Putative apoptosis inhibitor 5 | ← | |||||
| 30K protein 26 | ← | |||||
| ubiquitin-proteasome | ||||||
| Goliath E3 ubiquitin ligase | → | |||||
| Ubiquitin-conjugating enzyme E2 J1-like | → | |||||
| midgut remodeling—cuticle | ||||||
| CPH43 | → | |||||
| Urbain precursor | → | |||||
| 37 kDa protease precursor | → | |||||
| iron metabolism | ||||||
| Ferritin | → | |||||
| Transferrin | → | → | ||||
| ribosomal proteins | ||||||
| L11 | → | |||||
| P0 | → | |||||
| unknown | ||||||
| LOC101735726 | ← | |||||
| Protein KGM_04122 | ← | |||||
| Protein KGM16290 | ← | |||||
| Similar to CG10527 | → | |||||
| Similar to CG8927 | → | |||||
| Unknown secreted protein | → | |||||
| 30 kDa protein | → | |||||
Only genes confirmed by qRT-PCR (more than 2-fold difference in response) are shown. Induced and repressed genes are marked with up and down arrows respectively. Empty cells indicate that the particular gene was not tested by qRT-PCR for differential expression in the particular study. Abbreviations: SH: subtractive hybridization, MA: microarray, DS: deep sequencing. P50, 4008 and Daizo refer to silkworm strains.