Table 3. Classification of genes that are induced or repressed following pathogenic BmCPV infection: comparison among different relevant studies.
Genes | SH (p50) [ 17 ] | MA (p50) [ 18 ] | DS (4008) [ 15 ] | DS (4008) [ 16 ] | DS (p50) [ 16 ] | D (DaiSzo) our study |
---|---|---|---|---|---|---|
digestive enzymes (proteases, lipases, nucleases) | ||||||
Acidic lipase | ← | |||||
Alkaline nuclease | → | |||||
Chymotrypsin-like | ← | ← | ||||
Hemocyte protease-2 | → | |||||
Insect intestinal lipase-6 | ← | |||||
Lipase-1 | → | ← | ← | |||
Pancreatic lipase-like | → | |||||
Serine protease | ← | |||||
Trypsin-like | ← | ← | ||||
Zinc carboxypeptidase A1 | ← | |||||
detoxification/metabolism | ||||||
Antennal esterase CXE14 | ← | |||||
Aquaporin | → | |||||
Cytochrome P450 | → | |||||
Dicarbonyl/L-xylulose reductase | ← | |||||
Esterase FE4 | ← | |||||
Farnesyl diphosphate synthase | → | |||||
Fatty acid binding protein | ← | |||||
Similar to carboxylesterase | ← | |||||
Sugar transporter | ← | |||||
Putative galactose UDP 4-epimerase | → | |||||
stress response | ||||||
eIF-4E-1 | → | |||||
HSP 20.8 | → | |||||
HSP 23.7 | → | |||||
HSP25.4 | → | |||||
signaling | ||||||
Calreticulin | → | |||||
Coiled-coil & C2 domain-containing 2A | → | |||||
Ecdysteroid-22 kinase | → | |||||
Famesoic acid O-methyltransferase | → | |||||
FK506-binding protein precursor | → | |||||
GTP:AMP phosphotransferase | ← | |||||
GTP-binding protein RAB2 | → | |||||
Inorganic phosphate transporter 1 | ← | |||||
Juvenile hormone diol kinase | → | → | ||||
Neuropeptide-like 4E (NPLP4E) | ← | |||||
Palmityl transferase (P260) | ← | ← | ||||
Protein kinase C inhibitor | → | |||||
Troponin-C | → | |||||
immune response | ||||||
Antitrypsin precursor | ← | |||||
Insulin-binding protein 2 | → | → | → | |||
Peptidoglycan recognition protein LB-like | → | |||||
Serpin-5 | → | |||||
Serpin-28 | → | |||||
Thioredoxin-like | → | |||||
Tumor necrosis factor 13 (TNFSF13) | → | |||||
RNAi | ||||||
Argonaute-2 | → | |||||
Dicer-2 | → | |||||
apoptosis | ||||||
Carboxypeptidase B | → | |||||
Caspase-8 | → | |||||
Inhibitor-of-apoptosis | ← | |||||
Programmed cell death protein 5 | → | |||||
Putative apoptosis inhibitor 5 | ← | |||||
30K protein 26 | ← | |||||
ubiquitin-proteasome | ||||||
Goliath E3 ubiquitin ligase | → | |||||
Ubiquitin-conjugating enzyme E2 J1-like | → | |||||
midgut remodeling—cuticle | ||||||
CPH43 | → | |||||
Urbain precursor | → | |||||
37 kDa protease precursor | → | |||||
iron metabolism | ||||||
Ferritin | → | |||||
Transferrin | → | → | ||||
ribosomal proteins | ||||||
L11 | → | |||||
P0 | → | |||||
unknown | ||||||
LOC101735726 | ← | |||||
Protein KGM_04122 | ← | |||||
Protein KGM16290 | ← | |||||
Similar to CG10527 | → | |||||
Similar to CG8927 | → | |||||
Unknown secreted protein | → | |||||
30 kDa protein | → |
Only genes confirmed by qRT-PCR (more than 2-fold difference in response) are shown. Induced and repressed genes are marked with up and down arrows respectively. Empty cells indicate that the particular gene was not tested by qRT-PCR for differential expression in the particular study. Abbreviations: SH: subtractive hybridization, MA: microarray, DS: deep sequencing. P50, 4008 and Daizo refer to silkworm strains.