Table 3. Overlap between cavity pairs with significant correlations (CSCs) and known allosteric couplings.

Protein	FS residues	AS residues	human CSCs	species CSCs
ALDOLASE	D33,S35,S38,K107,K146,R148 E187,E189K229,S271,R303,L356	C72,C338	YES	YES
ANNEXIN	M28,G30,G32,K70,E72,L73 E78,G183,K186,G188,E228	W185	YES	NO
TRANSFERRIN	R140,K203,K293	E80,Y82,H246,K293	NO	——
RBP	L35	L63-D68,G92-K99	YES	NO
PNP	F199,E200,V216,M218,N242 V244,V259	——	——	——
HSP 90	D83,N51,G137,F138	K194,L220,Q287,P295	YES	YES
CYCLOPHILIN	H54,R55,F60,M61,Q63,N102 Q111,F113,W121,L122,H126	C51,H53,H69,K150,T151,K154	——	——
INTERLEUKIN-1beta	N87-K101	W118	NO	NO
NDK	——	——	——	NO

The residue numbers of the functional (FS) and allosteric (AS) site residues were obtained from the literature (see main body of the article). In the fourth and fifth columns we mention whether there was any CSC with a cavity overlapping the FS and the other the AS: YES (at least one CSC existed), NO (no overlapping CSC was found), dashed line (——, functional information was lacking and the comparison could not be performed).