Table 3. Subgroup-analysis of the association between MMP-2 expression and overall survival.

Subgroup	No. of studies	No. of patients	HR(95%CI)	Heterogeneity
				χ2	P	I2 (%)
Overall effect	8	1492	1.53(1.29–1.82)	5.85	0.558	0.00
County
Asia	4	670	1.47(1.17–1.84)	3.71	0.295	19.00
Europe	4	822	1.62(1.25–2.10)	1.83	0.608	0.00
Sample size
<200	5	547	1.68(1.31–2.16)	2.83	0.587	0.00
≥200	3	945	1.41(1.11–1.78)	1.99	0.369	0.00
Evaluation standards
percentage	4	972	1.87(1.36–2.59)	1.14	0.769	0.00
CS	4	520	1.41(1.15–1.73)	2.58	0.461	0.00
HR estimate
Reported in text	5	1151	1.48(1.20–1.83)	2.87	0.58	0.00
By estimated	3	341	1.63(1.21–2.21)	2.71	0.258	26.10
Analysis model
Univariate	4	563	1.43(1.17–1.75)	4.08	0.253	26.40
Multivariate	4	929	1.81(1.31–2.50)	0.28	0.964	0.00
Recruitment time
-1995	3	812	1.43(1.13–1.81)	3.10	0.213	35.40
1995-	2	250	1.56(1.18–2.04)	0.42	0.516	0.00