Age: <2 and >50 years |
Comorbidities (liver disease, splenectomy, diabetes mellitus, malignancy, HIV, vascular disease) |
Pre-existing edema in the area of bite |
Chronic alcohol consumption |
Use of immunosuppressive drugs (including chronic steroids) |
Moderate to severe wounds |
Puncture wound, large avulsion, crush injury |
Presence of foreign material and/or heavily contaminated wound |
Scalp or face in infants and young children |
Associated injuries to bone, joint, tendon sheath, or neurovascular structures |
Adjacent to prosthetic joint |
Delay in care >24 h |
Improper wound cleansing or debridement |