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. 2015 Mar 27;10(3):e0122228. doi: 10.1371/journal.pone.0122228

Fig 6. FSCN1 is a direct target of miR-145.

Fig 6

(A) There are four putative binding sites of miR-145 in the 3′ UTR of FSCN1. (B) Relative luciferase activity of SUNE-1 and CNE-2 cells after co-transfection with wild-type (Wt) or mutant (Mt) FSCN1 3′ UTR reporter genes and miR-145 mimics or control. (C) Quantification of FSCN1 mRNA expression in SUNE-1 and CNE-2 cells transfected with miR-145 mimics or miRNA control. (D) Quantification of FSCN1 protein expression in SUNE-1 and CNE-2 cells transfected with miR-145 mimics or miRNA control. (E) Spearman’s correlation analysis of miR-145 and FSCN1 expression in NPC tissues (n = 18); a significant inverse correlation was observed.